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17 August 2007 |
Kampala – On
July 13, a man, 29, died in a hospital in Kampala, Uganda. All the
clinical signs he showed immediately raised the concern of the medical
staff. By the end of the month, the positive result of the test for
Hemorrhagic Fever of Marburg type was confirmed.
Another hospitalised patient, 21, tested positive for Marburg Hemorrhagic
Fever. He was discharged on July 9 and since then no more cases have
been detected. Both patients worked in a mine located in Kamwenge District
(about 250 km west from Kampala)
After the first case was reported, a task force with the World Health
Organisation (WHO), Uganda Ministry of Health, Centre for Disease Control
(CDC), MSF and others was organized to follow up the people who had
potentially been in touch with the confirmed case.
The incubation time (time between getting infected and the first symptoms)
is considered to be of maximum 21 days. However, the task force agreed
to continue the follow-up and the search for eventual new cases for
the double of this time, so for 42 days, before declaring the end of
the outbreak.
An isolation area in the Mulago hospital in Kampala and a second in
a health structure close to Kamwenge, where the cases had originated,
have been prepared, and the health staff in these facilities has been
trained to be able to respond to this type of emergencies.
Experience from the past
MSF has been monitoring the situation carefully using our experience
in previous Marburg epidemics. In Uige, Angola, in 2005, the MSF teams
had to deal with a huge growth of the disease that had a high mortality.
Only supportive treatment for Marburg HF can be offered to the patients
and the case fatality is high (50-90%). Outbreak control procedures
are effective at controlling its spread.
Currently, the national data has two confirmed cases (positive laboratory
result for Marburg Hemorrhagic Fever); out of these, one death and
one survivor. So far 202 contacts have been followed (105 in Kamwenge
/ Ibanda; 97 in Kampala / Kayunga).
MSF teams have supported the control and surveillance of the possible
Marburg cases in Kampala and Kamwenge.
In Mulago National Hospital, located in Kampala, MSF has provided
support with technical assistance in case management of the “alert
patients” who arrived at the hospital, meaning patients with
symptoms that are similar to the ones in Marburg HF. No more positive
cases have been detected. In addition MSF has provided comprehensive
case management training to the core staff of Mulago Hospital.
In Kamwenge and Ibanda district, MSF has provided information sessions
to the health structures and medical material, drugs and related supplies
based on an estimation for an isolation Unit for three to five patients
for 25 days. In Ibanda Missionary Hospital and in one of the Kicheche
health centres MSF set up an isolation unit with all the means needed
for responding to alert cases.
MSF has sent four international volunteers to give additional support
to the teams already on the ground and hired five new local staff.
Also MSF paid 18 of the core staff for Mulago Hospital of Kampala to
work in the Isolation Unit, from August 13 to August 28.
Marburg hemorrhagic
fever
Marburg haemorrhagic fever is a severe and highly fatal disease
caused by a virus from the same family as the one that causes
Ebola haemorrhagic fever. These viruses are among the most virulent
pathogens known to infect humans. Both diseases are rare, but
have a capacity to cause dramatic outbreaks with high fatality
levels.
Illness caused by the Marburg virus begins abruptly, with severe
headaches and discomfort. Many patients develop severe haemorrhagic
manifestations between days five and seven, and fatal cases usually
have some form of bleeding, often from multiple locations. The
disease has no vaccine and no specific treatment. Case fatality
rates have varied greatly, from 25% in the initial laboratory-associated
outbreak in 1967, to more than 80% in the Democratic Republic
of Congo from 1998-2000, to even higher in the outbreak that
began in Angola in late 2004.
MSF in Marburg epidemics
The MSF reaction includes setting up and managing the isolation
units where patients are cared for; maintaining hospital infection
control; and reinforcing universal precautions.
MSF also assists with case finding and contact tracing, ensuring
safe burial practices, and maintaining water and sanitation systems,
including disinfection. Teams also provide essential community
education and epidemiological monitoring and analysis. MSF sometimes
sets up additional emergency units around the main isolation
units.
Given the infectious nature of the disease, MSF teams have to
wear extensive bio-safety gear. This clothing is not only uncomfortable
to work in but often frightens local community members. That
makes MSF’s efforts to raise awareness among the community
even more important. |
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